Drug interactions
Artesunate + Axitinib
Severity: Minor
Artesunate and Axitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artesunate is converted to active dihydroartemisinin, which is cleared by UGT enzymes. Axitinib may inhibit UGT1A1 in vitro, which could raise dihydroartemisinin levels, but clinical significance is uncertain.
What this interaction means in plain words
Artesunate and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Artesunate belongs to Anti Parasitic; Axitinib belongs to Oncology.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of dihydroartemisinin by axitinib.
What to do
No dose change is usually needed; monitor for artesunate adverse effects such as hemolysis or liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Eltrombopag Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Nevirapine Moderate
- Artesunate + Phenytoin Moderate
Frequently asked questions
Can I take Artesunate with Axitinib?
MediHelp rates the interaction as minor. Artesunate and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artesunate is converted to active dihydroartemisinin, which is cleared by UGT enzymes. Axitinib may inhibit UGT1A1 in vitro, which could raise dihydroartemisinin levels, but clinical significance is uncertain.
How serious is the interaction between Artesunate and Axitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for artesunate adverse effects such as hemolysis or liver enzyme elevation.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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