Drug interactions
Artesunate + Sorafenib
Severity: Minor
Artesunate and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib inhibits UGT1A1, which may reduce clearance of dihydroartemisinin, the active metabolite of artesunate. Exposure could increase, though clinical consequences are uncertain.
What this interaction means in plain words
Artesunate and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Artesunate belongs to Anti Parasitic; Sorafenib belongs to Oncology.
Why it happens
Sorafenib inhibits UGT-mediated glucuronidation of dihydroartemisinin.
What to do
No routine dose change is needed. Monitor for increased artesunate adverse effects such as hemolysis or liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Eltrombopag Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Nevirapine Moderate
- Artesunate + Phenytoin Moderate
Frequently asked questions
Can I take Artesunate with Sorafenib?
MediHelp rates the interaction as minor. Artesunate and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sorafenib inhibits UGT1A1, which may reduce clearance of dihydroartemisinin, the active metabolite of artesunate. Exposure could increase, though clinical consequences are uncertain.
How serious is the interaction between Artesunate and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased artesunate adverse effects such as hemolysis or liver enzyme elevation.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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