Drug interactions
Artesunate + Vandetanib
Severity: Moderate
Artesunate and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artesunate is converted to active dihydroartemisinin, which is cleared by glucuronidation. Inhibiting UGT enzymes may raise dihydroartemisinin exposure, and vandetanib itself prolongs the QT interval, as can antimalarials.
What this interaction means in plain words
Artesunate and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Vandetanib belongs to Oncology.
Why it happens
Possible UGT inhibition raising dihydroartemisinin levels; additive QT effects are also possible.
What to do
Avoid if an alternative is available. If used together, obtain an ECG and monitor electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Eltrombopag Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Nevirapine Moderate
- Artesunate + Phenytoin Moderate
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Artesunate with Vandetanib?
MediHelp rates the interaction as moderate. Artesunate and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artesunate is converted to active dihydroartemisinin, which is cleared by glucuronidation. Inhibiting UGT enzymes may raise dihydroartemisinin exposure, and vandetanib itself prolongs the QT interval, as can antimalarials.
How serious is the interaction between Artesunate and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available. If used together, obtain an ECG and monitor electrolytes.
What other medicines interact with Artesunate?
MediHelp also lists interactions of Artesunate with, for example, Rifampicin, Carbamazepine, Eltrombopag. The full list is on the Artesunate page.
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