Drug interactions
Asciminib + Fentanyl
Severity: Moderate
Asciminib and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asciminib may increase exposure to CYP3A4 substrates with narrow therapeutic windows, such as fentanyl. This could increase opioid effects including respiratory depression.
What this interaction means in plain words
Asciminib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Fentanyl belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 by asciminib reduces fentanyl clearance.
What to do
Monitor for sedation and respiratory depression. Consider reducing the fentanyl dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Asciminib with Fentanyl?
MediHelp rates the interaction as moderate. Asciminib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asciminib may increase exposure to CYP3A4 substrates with narrow therapeutic windows, such as fentanyl. This could increase opioid effects including respiratory depression.
How serious is the interaction between Asciminib and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression. Consider reducing the fentanyl dose.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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