Drug interactions
Asciminib + Dihydroergotamine
Severity: Major
Asciminib and Dihydroergotamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asciminib may raise dihydroergotamine levels. Elevated ergot exposure risks vasospasm and ischemia.
What this interaction means in plain words
Asciminib and Dihydroergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asciminib belongs to Oncology; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by asciminib reduces dihydroergotamine metabolism.
What to do
Avoid the combination if possible. If used, monitor for peripheral ischemia, paresthesia and cold extremities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asciminib
- Asciminib + Clarithromycin Major
- Asciminib + Ergotamine Major
- Asciminib + Haloperidol Major
- Asciminib + Methadone Major
- Asciminib + Moxifloxacin Major
- Asciminib + Atorvastatin Moderate
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Asciminib with Dihydroergotamine?
MediHelp rates the interaction as major. Asciminib and Dihydroergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Asciminib may raise dihydroergotamine levels. Elevated ergot exposure risks vasospasm and ischemia.
How serious is the interaction between Asciminib and Dihydroergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor for peripheral ischemia, paresthesia and cold extremities.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Ergotamine, Haloperidol. The full list is on the Asciminib page.
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