Drug interactions
Asciminib + Methotrexate
Severity: Moderate
Asciminib and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asciminib inhibits the breast cancer resistance protein (BCRP) efflux transporter in vitro and may raise exposure to BCRP substrates such as methotrexate. Higher methotrexate levels could increase myelosuppression, mucositis, hepatic and renal toxicity.
What this interaction means in plain words
Asciminib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Asciminib inhibits BCRP-mediated efflux, which may increase systemic exposure to methotrexate.
What to do
Monitor blood counts, liver enzymes and renal function more closely when combining, and reduce the methotrexate dose if toxicity appears. Consult the methotrexate labeling for dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asciminib and Methotrexate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Asciminib
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Asciminib with Methotrexate?
MediHelp rates the interaction as moderate. Asciminib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asciminib inhibits the breast cancer resistance protein (BCRP) efflux transporter in vitro and may raise exposure to BCRP substrates such as methotrexate. Higher methotrexate levels could increase myelosuppression, mucositis, hepatic and renal toxicity.
How serious is the interaction between Asciminib and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver enzymes and renal function more closely when combining, and reduce the methotrexate dose if toxicity appears. Consult the methotrexate labeling for dose adjustment.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
