Drug interactions
Asenapine + Azithromycin
Severity: Moderate
Asenapine and Azithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QT interval, and using them together may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Asenapine and Azithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Azithromycin belongs to Anti Bacterial.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG and correct electrolytes before and during combined use in at-risk patients. Choose an alternative antibiotic if the patient has known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Azithromycin?
MediHelp rates the interaction as moderate. Asenapine and Azithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lengthen the QT interval, and using them together may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Asenapine and Azithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolytes before and during combined use in at-risk patients. Choose an alternative antibiotic if the patient has known QT prolongation.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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