Drug interactions
Asenapine + Benazepril
Severity: Moderate
Asenapine and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension and syncope, and these effects may be heightened in patients on ACE inhibitors, especially at initiation.
What this interaction means in plain words
Asenapine and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Benazepril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade by asenapine and ACE inhibition.
What to do
Check orthostatic blood pressure when starting asenapine or titrating the dose, and adjust benazepril if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Benazepril?
MediHelp rates the interaction as moderate. Asenapine and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension and syncope, and these effects may be heightened in patients on ACE inhibitors, especially at initiation.
How serious is the interaction between Asenapine and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check orthostatic blood pressure when starting asenapine or titrating the dose, and adjust benazepril if hypotension develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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