Drug interactions
Asenapine + Carbidopa
Severity: Moderate
Asenapine and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension, and carbidopa given with levodopa can also lower blood pressure. In addition, antipsychotic dopamine blockade may oppose the antiparkinsonian effect of levodopa. Carbidopa alone has little direct effect.
What this interaction means in plain words
Asenapine and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Carbidopa belongs to Central Nervous System.
Why it happens
Additive hypotension, plus dopamine receptor antagonism opposing dopaminergic therapy.
What to do
Monitor blood pressure and orthostatic symptoms and parkinsonian motor control. Prefer a low-D2-affinity antipsychotic in Parkinson disease if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Asenapine with Carbidopa?
MediHelp rates the interaction as moderate. Asenapine and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension, and carbidopa given with levodopa can also lower blood pressure. In addition, antipsychotic dopamine blockade may oppose the antiparkinsonian effect of levodopa. Carbidopa alone has little direct effect.
How serious is the interaction between Asenapine and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms and parkinsonian motor control. Prefer a low-D2-affinity antipsychotic in Parkinson disease if feasible.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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