Drug interactions
Asenapine + Chlordiazepoxide-clidinium
Severity: Moderate
Asenapine and Chlordiazepoxide-clidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and may impair alertness and coordination when combined. Hypotension and dizziness may also be additive.
What this interaction means in plain words
Asenapine and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression.
What to do
Monitor sedation and blood pressure, particularly at initiation. Reduce doses if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as moderate. Asenapine and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and may impair alertness and coordination when combined. Hypotension and dizziness may also be additive.
How serious is the interaction between Asenapine and Chlordiazepoxide-clidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, particularly at initiation. Reduce doses if excessive drowsiness occurs.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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