Drug interactions
Asenapine + Cimetidine
Severity: Minor
Asenapine and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may raise asenapine concentrations by slowing its metabolism. Asenapine labeling indicates only a small effect from cimetidine, so clinical significance is limited.
What this interaction means in plain words
Asenapine and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits CYP1A2, a main route of asenapine metabolism.
What to do
No dose change is usually needed; monitor for sedation, orthostasis and other asenapine adverse effects when starting or stopping cimetidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Cimetidine?
MediHelp rates the interaction as minor. Asenapine and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may raise asenapine concentrations by slowing its metabolism. Asenapine labeling indicates only a small effect from cimetidine, so clinical significance is limited.
How serious is the interaction between Asenapine and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for sedation, orthostasis and other asenapine adverse effects when starting or stopping cimetidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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