Drug interactions
Asenapine + Ciprofloxacin
Severity: Moderate
Asenapine and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin and asenapine can both prolong the QT interval, so together they may increase the risk of ventricular arrhythmia. Ciprofloxacin may also raise asenapine levels by inhibiting CYP1A2, intensifying its adverse effects.
What this interaction means in plain words
Asenapine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation plus inhibition of CYP1A2-mediated asenapine metabolism by ciprofloxacin.
What to do
Obtain a baseline ECG and correct hypokalemia or hypomagnesemia before combining. Monitor the QTc and for excess sedation or hypotension; consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Ciprofloxacin?
MediHelp rates the interaction as moderate. Asenapine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin and asenapine can both prolong the QT interval, so together they may increase the risk of ventricular arrhythmia. Ciprofloxacin may also raise asenapine levels by inhibiting CYP1A2, intensifying its adverse effects.
How serious is the interaction between Asenapine and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia or hypomagnesemia before combining. Monitor the QTc and for excess sedation or hypotension; consider an alternative antibiotic in high-risk patients.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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