Drug interactions
Asenapine + Dapagliflozin-metformin
Severity: Moderate
Asenapine and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has been associated with hyperglycemia and altered glucose tolerance. In patients with diabetes this may reduce the effectiveness of dapagliflozin-metformin and worsen glycemic control.
What this interaction means in plain words
Asenapine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as atypical antipsychotics may reduce insulin sensitivity and alter glucose metabolism.
What to do
Check blood glucose and HbA1c at baseline and periodically during asenapine therapy, and titrate antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Asenapine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has been associated with hyperglycemia and altered glucose tolerance. In patients with diabetes this may reduce the effectiveness of dapagliflozin-metformin and worsen glycemic control.
How serious is the interaction between Asenapine and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose and HbA1c at baseline and periodically during asenapine therapy, and titrate antidiabetic treatment as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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