Drug interactions
Asenapine + Deutetrabenazine
Severity: Moderate
Asenapine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect dopaminergic signalling, so combining them can raise the risk of parkinsonism, akathisia and neuroleptic malignant syndrome. Additive sedation and a possible small additive effect on QT interval may also occur.
What this interaction means in plain words
Asenapine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic dopamine antagonism (postsynaptic D2 blockade plus presynaptic VMAT2 inhibition with dopamine depletion), with additive CNS depression.
What to do
Monitor for extrapyramidal symptoms, akathisia, rigidity and hyperthermia, and reduce the dose of one agent if movement symptoms emerge. Consider an ECG if other QT-prolonging drugs or risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Asenapine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Asenapine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs affect dopaminergic signalling, so combining them can raise the risk of parkinsonism, akathisia and neuroleptic malignant syndrome. Additive sedation and a possible small additive effect on QT interval may also occur.
How serious is the interaction between Asenapine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, akathisia, rigidity and hyperthermia, and reduce the dose of one agent if movement symptoms emerge. Consider an ECG if other QT-prolonging drugs or risk factors are present.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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