Drug interactions
Asenapine + Eszopiclone
Severity: Moderate
Asenapine and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine commonly causes somnolence, and eszopiclone is a sedative-hypnotic. Together they may produce greater sedation, dizziness and impaired coordination, increasing fall risk.
What this interaction means in plain words
Asenapine and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Eszopiclone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective eszopiclone dose and monitor for oversedation, orthostasis and falls. Advise patients not to drive until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Eszopiclone?
MediHelp rates the interaction as moderate. Asenapine and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine commonly causes somnolence, and eszopiclone is a sedative-hypnotic. Together they may produce greater sedation, dizziness and impaired coordination, increasing fall risk.
How serious is the interaction between Asenapine and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eszopiclone dose and monitor for oversedation, orthostasis and falls. Advise patients not to drive until tolerance is established.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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