Drug interactions
Asenapine + Fostemsavir
Severity: Moderate
Asenapine and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, although fostemsavir does so mainly at supratherapeutic doses. The combination may add modestly to arrhythmia risk in patients with other risk factors.
What this interaction means in plain words
Asenapine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs, and correct potassium and magnesium. Avoid exceeding recommended fostemsavir doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Asenapine with Fostemsavir?
MediHelp rates the interaction as moderate. Asenapine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, although fostemsavir does so mainly at supratherapeutic doses. The combination may add modestly to arrhythmia risk in patients with other risk factors.
How serious is the interaction between Asenapine and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs, and correct potassium and magnesium. Avoid exceeding recommended fostemsavir doses.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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