Drug interactions
Asenapine + Levocetirizine
Severity: Minor
Asenapine and Levocetirizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine commonly causes somnolence, and levocetirizine can add to drowsiness in some patients. This may impair alertness and driving ability.
What this interaction means in plain words
Asenapine and Levocetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Levocetirizine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antagonism and the sedating receptor effects of asenapine.
What to do
Counsel patients about additive drowsiness and caution with driving. Monitor sedation and adjust therapy only if it becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levocetirizine
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Levocetirizine?
MediHelp rates the interaction as minor. Asenapine and Levocetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine commonly causes somnolence, and levocetirizine can add to drowsiness in some patients. This may impair alertness and driving ability.
How serious is the interaction between Asenapine and Levocetirizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and caution with driving. Monitor sedation and adjust therapy only if it becomes troublesome.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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