Drug interactions
Asenapine + Linezolid
Severity: Moderate
Asenapine and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits monoamine oxidase and asenapine acts on multiple serotonin and dopamine receptors, so serotonin toxicity is theoretically possible. Additive neuroleptic malignant syndrome features are also conceivable but unproven.
What this interaction means in plain words
Asenapine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic and dopaminergic effects from MAO inhibition by linezolid plus asenapine receptor activity.
What to do
Monitor for agitation, tremor, clonus, hyperthermia, rigidity and autonomic instability throughout the linezolid course. Discontinue the agents and provide supportive care if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Linezolid?
MediHelp rates the interaction as moderate. Asenapine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits monoamine oxidase and asenapine acts on multiple serotonin and dopamine receptors, so serotonin toxicity is theoretically possible. Additive neuroleptic malignant syndrome features are also conceivable but unproven.
How serious is the interaction between Asenapine and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia, rigidity and autonomic instability throughout the linezolid course. Discontinue the agents and provide supportive care if toxicity appears.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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