Drug interactions
Asenapine + Loxapine
Severity: Moderate
Asenapine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics are sedating and together may cause greater drowsiness, orthostatic hypotension, and psychomotor impairment. Additive dopamine blockade also increases the risk of extrapyramidal effects.
What this interaction means in plain words
Asenapine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and combined D2 and antihistamine receptor antagonism.
What to do
Avoid combining where possible; if both are needed, use the lowest effective doses and monitor sedation, blood pressure, and movement symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Loxapine?
MediHelp rates the interaction as moderate. Asenapine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antipsychotics are sedating and together may cause greater drowsiness, orthostatic hypotension, and psychomotor impairment. Additive dopamine blockade also increases the risk of extrapyramidal effects.
How serious is the interaction between Asenapine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are needed, use the lowest effective doses and monitor sedation, blood pressure, and movement symptoms.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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