Drug interactions
Asenapine + Methsuximide
Severity: Moderate
Asenapine and Methsuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methsuximide commonly causes drowsiness and dizziness, which may be increased by asenapine. Antipsychotics may also lower the seizure threshold, which can oppose anticonvulsant control.
What this interaction means in plain words
Asenapine and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Methsuximide belongs to Central Nervous System.
Why it happens
Additive CNS depression; antipsychotics may also lower seizure threshold.
What to do
Monitor sedation and seizure frequency after starting or changing doses. Adjust anticonvulsant therapy if seizure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Methsuximide
- Amisulpride + Methsuximide Moderate
- Amobarbital + Methsuximide Moderate
- Apalutamide + Methsuximide Moderate
- Brexpiprazole + Methsuximide Moderate
- Brivaracetam + Methsuximide Moderate
- Cariprazine + Methsuximide Moderate
Frequently asked questions
Can I take Asenapine with Methsuximide?
MediHelp rates the interaction as moderate. Asenapine and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methsuximide commonly causes drowsiness and dizziness, which may be increased by asenapine. Antipsychotics may also lower the seizure threshold, which can oppose anticonvulsant control.
How serious is the interaction between Asenapine and Methsuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure frequency after starting or changing doses. Adjust anticonvulsant therapy if seizure control worsens.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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