Drug interactions
Apalutamide + Methsuximide
Severity: Moderate
Apalutamide and Methsuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower concentrations of methsuximide's active metabolite, which is cleared partly by CYP enzymes including CYP2C19. Loss of seizure control is possible.
What this interaction means in plain words
Apalutamide and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Methsuximide belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP2C19 and CYP3A4, increasing metabolism of methsuximide and its active metabolite.
What to do
Monitor seizure frequency and, where available, serum levels of the active metabolite, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Methsuximide
- Amisulpride + Methsuximide Moderate
- Amobarbital + Methsuximide Moderate
- Asenapine + Methsuximide Moderate
- Brexpiprazole + Methsuximide Moderate
- Brivaracetam + Methsuximide Moderate
- Cariprazine + Methsuximide Moderate
Frequently asked questions
Can I take Apalutamide with Methsuximide?
MediHelp rates the interaction as moderate. Apalutamide and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower concentrations of methsuximide's active metabolite, which is cleared partly by CYP enzymes including CYP2C19. Loss of seizure control is possible.
How serious is the interaction between Apalutamide and Methsuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and, where available, serum levels of the active metabolite, adjusting the dose as needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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