Drug interactions
Amobarbital + Methsuximide
Severity: Moderate
Amobarbital and Methsuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates may alter the concentrations of methsuximide and its active metabolite, while methsuximide can in turn affect barbiturate levels. The direction and size of the effect vary between patients.
What this interaction means in plain words
Amobarbital and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Methsuximide belongs to Central Nervous System.
Why it happens
Mutual changes in hepatic metabolism, with barbiturate enzyme induction affecting the clearance of methsuximide's active metabolite.
What to do
Monitor seizure control and sedation, and measure serum levels of the antiepileptic drugs when therapy is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amobarbital and Methsuximide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Methsuximide
- Amisulpride + Methsuximide Moderate
- Apalutamide + Methsuximide Moderate
- Asenapine + Methsuximide Moderate
- Brexpiprazole + Methsuximide Moderate
- Brivaracetam + Methsuximide Moderate
- Cariprazine + Methsuximide Moderate
Frequently asked questions
Can I take Amobarbital with Methsuximide?
MediHelp rates the interaction as moderate. Amobarbital and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates may alter the concentrations of methsuximide and its active metabolite, while methsuximide can in turn affect barbiturate levels. The direction and size of the effect vary between patients.
How serious is the interaction between Amobarbital and Methsuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and measure serum levels of the antiepileptic drugs when therapy is changed.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
