Drug interactions
Asenapine + Nebivolol
Severity: Moderate
Asenapine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension, which adds to the blood pressure lowering of nebivolol. Asenapine is also a weak CYP2D6 inhibitor and may slightly increase nebivolol exposure.
What this interaction means in plain words
Asenapine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade by asenapine plus beta blockade, with weak CYP2D6 inhibition.
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation. Adjust antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Nebivolol?
MediHelp rates the interaction as moderate. Asenapine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension, which adds to the blood pressure lowering of nebivolol. Asenapine is also a weak CYP2D6 inhibitor and may slightly increase nebivolol exposure.
How serious is the interaction between Asenapine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation. Adjust antihypertensive dose if hypotension develops.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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