Drug interactions
Asenapine + Oxymorphone
Severity: Moderate
Asenapine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is sedating and can cause orthostatic hypotension, so combined use with oxymorphone may increase drowsiness, hypotension and respiratory depression. Elderly or debilitated patients are at particular risk.
What this interaction means in plain words
Asenapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and hypotensive effects from opioid agonism and antipsychotic receptor antagonism.
What to do
Start oxymorphone at a low dose and titrate while monitoring sedation, blood pressure and respiratory rate. Counsel patients to rise slowly and avoid driving until tolerance is clear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Oxymorphone?
MediHelp rates the interaction as moderate. Asenapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is sedating and can cause orthostatic hypotension, so combined use with oxymorphone may increase drowsiness, hypotension and respiratory depression. Elderly or debilitated patients are at particular risk.
How serious is the interaction between Asenapine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start oxymorphone at a low dose and titrate while monitoring sedation, blood pressure and respiratory rate. Counsel patients to rise slowly and avoid driving until tolerance is clear.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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