Drug interactions
Asenapine + Procarbazine
Severity: Moderate
Asenapine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibiting activity, and combining it with an antipsychotic may increase the risk of serotonin toxicity or neuroleptic malignant syndrome. Evidence is limited and based largely on mechanistic reasoning, but the reactions can be serious. Procarbazine also causes sedation, which adds to that of asenapine.
What this interaction means in plain words
Asenapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine combined with dopamine and serotonin receptor antagonism by asenapine.
What to do
Monitor for agitation, hyperthermia, rigidity, autonomic instability and clonus, and stop both drugs if these occur. Educate patients and carers about early warning symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Asenapine with Procarbazine?
MediHelp rates the interaction as moderate. Asenapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibiting activity, and combining it with an antipsychotic may increase the risk of serotonin toxicity or neuroleptic malignant syndrome. Evidence is limited and based largely on mechanistic reasoning, but the reactions can be serious. Procarbazine also causes sedation, which adds to that of asenapine.
How serious is the interaction between Asenapine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, rigidity, autonomic instability and clonus, and stop both drugs if these occur. Educate patients and carers about early warning symptoms.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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