Drug interactions
Asenapine + Quizartinib
Severity: Major
Asenapine and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and asenapine can also prolong it. Combining them increases the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Asenapine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Avoid if possible; otherwise monitor ECG more frequently and keep potassium and magnesium normal. Reduce the quizartinib dose or stop if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Asenapine with Quizartinib?
MediHelp rates the interaction as major. Asenapine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and asenapine can also prolong it. Combining them increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Asenapine and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG more frequently and keep potassium and magnesium normal. Reduce the quizartinib dose or stop if QTc becomes markedly prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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