Drug interactions
Asenapine + Sertraline
Severity: Moderate
Asenapine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval, and sertraline may contribute a small additional effect. The risk of arrhythmia is greatest with other risk factors such as hypokalemia, bradycardia or structural heart disease.
What this interaction means in plain words
Asenapine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation; sertraline also weakly inhibits CYP2D6, which has a minor role in asenapine clearance.
What to do
Check ECG and electrolytes at baseline and after dose changes in patients with cardiac risk factors. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Sertraline?
MediHelp rates the interaction as moderate. Asenapine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can prolong the QT interval, and sertraline may contribute a small additional effect. The risk of arrhythmia is greatest with other risk factors such as hypokalemia, bradycardia or structural heart disease.
How serious is the interaction between Asenapine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and after dose changes in patients with cardiac risk factors. Avoid adding other QT-prolonging drugs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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