Drug interactions
Brexpiprazole + Sufentanil
Severity: Major
Brexpiprazole and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a highly potent opioid and, with brexpiprazole, can produce profound sedation, hypotension and respiratory depression. Opioid labeling advises caution when combining with other CNS depressants.
What this interaction means in plain words
Brexpiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedation.
What to do
Titrate sufentanil to the lowest effective dose and monitor respiratory rate, sedation and blood pressure continuously. Have airway support and reversal agents available in monitored settings.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brexpiprazole
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Brexpiprazole with Sufentanil?
MediHelp rates the interaction as major. Brexpiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a highly potent opioid and, with brexpiprazole, can produce profound sedation, hypotension and respiratory depression. Opioid labeling advises caution when combining with other CNS depressants.
How serious is the interaction between Brexpiprazole and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to the lowest effective dose and monitor respiratory rate, sedation and blood pressure continuously. Have airway support and reversal agents available in monitored settings.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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