Drug interactions
Asenapine + Sumatriptan
Severity: Moderate
Asenapine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with an antipsychotic that affects serotonin receptors has been associated with theoretical serotonin syndrome risk. Evidence of actual harm is sparse, and clinically significant reactions appear uncommon.
What this interaction means in plain words
Asenapine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects through 5-HT receptor activity; mechanism not firmly established.
What to do
Monitor for agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity after starting or increasing either drug. Educate the patient to seek help if these symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Asenapine with Sumatriptan?
MediHelp rates the interaction as moderate. Asenapine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with an antipsychotic that affects serotonin receptors has been associated with theoretical serotonin syndrome risk. Evidence of actual harm is sparse, and clinically significant reactions appear uncommon.
How serious is the interaction between Asenapine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity after starting or increasing either drug. Educate the patient to seek help if these symptoms appear.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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