Drug interactions
Asenapine + Tolbutamide
Severity: Moderate
Asenapine and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine may impair glycemic control and thereby reduce the effect of tolbutamide. Blood glucose may rise after asenapine is started.
What this interaction means in plain words
Asenapine and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Tolbutamide belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance and metabolic effects oppose antidiabetic action (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c at baseline and during therapy, and adjust the sulfonylurea dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Asenapine with Tolbutamide?
MediHelp rates the interaction as moderate. Asenapine and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine may impair glycemic control and thereby reduce the effect of tolbutamide. Blood glucose may rise after asenapine is started.
How serious is the interaction between Asenapine and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c at baseline and during therapy, and adjust the sulfonylurea dose as required.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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