Drug interactions
Asenapine + Tranylcypromine
Severity: Moderate
Asenapine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine blocks dopamine and serotonin receptors and may add to the monoamine effects of an MAO inhibitor. Rare serotonin toxicity, NMS and hypotension are possible.
What this interaction means in plain words
Asenapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with dopamine and serotonin receptor antagonism; additive hypotension and neurotoxicity risk.
What to do
Monitor mental status, temperature, muscle tone and blood pressure when starting or adjusting either drug. Discontinue and treat if serotonin syndrome or NMS signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Tranylcypromine?
MediHelp rates the interaction as moderate. Asenapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine blocks dopamine and serotonin receptors and may add to the monoamine effects of an MAO inhibitor. Rare serotonin toxicity, NMS and hypotension are possible.
How serious is the interaction between Asenapine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status, temperature, muscle tone and blood pressure when starting or adjusting either drug. Discontinue and treat if serotonin syndrome or NMS signs appear.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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