Drug interactions
Asenapine + Umeclidinium-vilanterol
Severity: Moderate
Asenapine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval, and vilanterol may add to arrhythmic risk through cardiac stimulation and hypokalemia. The effect is usually modest at inhaled doses.
What this interaction means in plain words
Asenapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and adrenergic stimulation.
What to do
Check ECG and electrolytes in patients with cardiac risk factors. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Asenapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can prolong the QT interval, and vilanterol may add to arrhythmic risk through cardiac stimulation and hypokalemia. The effect is usually modest at inhaled doses.
How serious is the interaction between Asenapine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors. Monitor for palpitations or syncope.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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