Drug interactions
Asenapine + Verapamil
Severity: Moderate
Asenapine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension, and verapamil also lowers blood pressure, so the combination may cause additive hypotension, dizziness and syncope. Both drugs can also affect cardiac conduction or QT interval to differing degrees.
What this interaction means in plain words
Asenapine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-adrenergic blockade and calcium channel blockade.
What to do
Monitor blood pressure, particularly orthostatic changes, when starting or adjusting either drug. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Verapamil?
MediHelp rates the interaction as moderate. Asenapine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension, and verapamil also lowers blood pressure, so the combination may cause additive hypotension, dizziness and syncope. Both drugs can also affect cardiac conduction or QT interval to differing degrees.
How serious is the interaction between Asenapine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly orthostatic changes, when starting or adjusting either drug. Advise patients to rise slowly.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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