Drug interactions
Asenapine + Voclosporin
Severity: Moderate
Asenapine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and asenapine can also prolong the QT interval. Combined use may raise the risk of ventricular arrhythmia, especially with electrolyte abnormalities or other risk factors.
What this interaction means in plain words
Asenapine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QTc prolongation through effects on cardiac repolarization.
What to do
Check baseline ECG and correct potassium and magnesium abnormalities before use. Repeat ECG monitoring if other QT-prolonging drugs are added or if symptoms such as palpitations or syncope develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Asenapine with Voclosporin?
MediHelp rates the interaction as moderate. Asenapine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and asenapine can also prolong the QT interval. Combined use may raise the risk of ventricular arrhythmia, especially with electrolyte abnormalities or other risk factors.
How serious is the interaction between Asenapine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium abnormalities before use. Repeat ECG monitoring if other QT-prolonging drugs are added or if symptoms such as palpitations or syncope develop.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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