Drug interactions
Asenapine + Vorinostat
Severity: Major
Asenapine and Vorinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and asenapine can add to this effect. The combination may increase the risk of ventricular arrhythmia, particularly when electrolytes are disturbed.
What this interaction means in plain words
Asenapine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Use an alternative antipsychotic if possible. Otherwise monitor ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Chlorpromazine + Vorinostat Major
- Clarithromycin + Vorinostat Major
Frequently asked questions
Can I take Asenapine with Vorinostat?
MediHelp rates the interaction as major. Asenapine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorinostat has been associated with QT prolongation, and asenapine can add to this effect. The combination may increase the risk of ventricular arrhythmia, particularly when electrolytes are disturbed.
How serious is the interaction between Asenapine and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antipsychotic if possible. Otherwise monitor ECG and keep potassium and magnesium normal.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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