Drug interactions
Anagrelide + Vorinostat
Severity: Major
Anagrelide and Vorinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, so combined use may increase the chance of torsades de pointes and other ventricular arrhythmias. Patients with cardiac disease or electrolyte abnormalities are at greatest risk.
What this interaction means in plain words
Anagrelide and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Prefer an alternative to one of the agents. If both are required, check a baseline ECG, correct potassium and magnesium, and repeat ECGs periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
- Clarithromycin + Vorinostat Major
Frequently asked questions
Can I take Anagrelide with Vorinostat?
MediHelp rates the interaction as major. Anagrelide and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have been associated with QT interval prolongation, so combined use may increase the chance of torsades de pointes and other ventricular arrhythmias. Patients with cardiac disease or electrolyte abnormalities are at greatest risk.
How serious is the interaction between Anagrelide and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to one of the agents. If both are required, check a baseline ECG, correct potassium and magnesium, and repeat ECGs periodically.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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