Drug interactions
Asenapine transdermal + Clomipramine
Severity: Moderate
Asenapine transdermal and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval and cause sedation. Together they may increase the risk of arrhythmia and CNS depression.
What this interaction means in plain words
Asenapine transdermal and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and additive CNS depression.
What to do
Check baseline and follow-up ECGs and correct potassium and magnesium abnormalities. Monitor for sedation and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Clomipramine?
MediHelp rates the interaction as moderate. Asenapine transdermal and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval and cause sedation. Together they may increase the risk of arrhythmia and CNS depression.
How serious is the interaction between Asenapine transdermal and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and follow-up ECGs and correct potassium and magnesium abnormalities. Monitor for sedation and avoid adding other QT-prolonging drugs.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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