Drug interactions
Asenapine transdermal + Clorazepate
Severity: Moderate
Asenapine transdermal and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a sedating antipsychotic, and combined with clorazepate it can increase somnolence, dizziness and orthostatic hypotension. Falls and impaired alertness are the main concerns.
What this interaction means in plain words
Asenapine transdermal and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and asenapine's antihistaminic and antiadrenergic activity.
What to do
Monitor sedation and blood pressure, and consider lower benzodiazepine doses. Counsel patients on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Asenapine transdermal with Clorazepate?
MediHelp rates the interaction as moderate. Asenapine transdermal and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is a sedating antipsychotic, and combined with clorazepate it can increase somnolence, dizziness and orthostatic hypotension. Falls and impaired alertness are the main concerns.
How serious is the interaction between Asenapine transdermal and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and consider lower benzodiazepine doses. Counsel patients on driving and alcohol.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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