Drug interactions
Asenapine transdermal + Oxaliplatin
Severity: Moderate
Asenapine transdermal and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval, and oxaliplatin has been associated with QT prolongation. Combined use may increase arrhythmia risk, particularly if electrolytes are disturbed.
What this interaction means in plain words
Asenapine transdermal and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check a baseline ECG and electrolytes, and correct potassium and magnesium. Monitor for palpitations or syncope and repeat the ECG if risk factors emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Oxaliplatin?
MediHelp rates the interaction as moderate. Asenapine transdermal and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can prolong the QT interval, and oxaliplatin has been associated with QT prolongation. Combined use may increase arrhythmia risk, particularly if electrolytes are disturbed.
How serious is the interaction between Asenapine transdermal and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and correct potassium and magnesium. Monitor for palpitations or syncope and repeat the ECG if risk factors emerge.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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