Drug interactions
Ashwagandha + Hydroxyzine
Severity: Minor
Ashwagandha and Hydroxyzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ashwagandha has reported sedative properties and may add to the drowsiness caused by hydroxyzine. Clinical data are limited and the effect is mostly predicted.
What this interaction means in plain words
Ashwagandha and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depressant effect; ashwagandha may have GABAergic activity.
What to do
Advise patients to watch for increased drowsiness and to avoid driving if sedated. Consider stopping the herbal product if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Ashwagandha with Hydroxyzine?
MediHelp rates the interaction as minor. Ashwagandha and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ashwagandha has reported sedative properties and may add to the drowsiness caused by hydroxyzine. Clinical data are limited and the effect is mostly predicted.
How serious is the interaction between Ashwagandha and Hydroxyzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for increased drowsiness and to avoid driving if sedated. Consider stopping the herbal product if excessive sedation occurs.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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