Drug interactions
Ashwagandha + Promethazine
Severity: Minor
Ashwagandha and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ashwagandha has sedative properties and may add to the drowsiness caused by promethazine. The effect is likely small but could impair alertness.
What this interaction means in plain words
Ashwagandha and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sedation; the herb's effect is thought to involve GABAergic activity but is not firmly established.
What to do
Advise patients to watch for added drowsiness and avoid driving until response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Ashwagandha with Promethazine?
MediHelp rates the interaction as minor. Ashwagandha and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ashwagandha has sedative properties and may add to the drowsiness caused by promethazine. The effect is likely small but could impair alertness.
How serious is the interaction between Ashwagandha and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for added drowsiness and avoid driving until response is known.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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