Drug interactions
Acetylsalicylic acid + Bumetanide
Severity: Moderate
Acetylsalicylic acid and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin, particularly at analgesic doses, can reduce the diuretic and natriuretic response to loop diuretics and may impair renal function in volume-depleted patients. Bumetanide can also raise salicylate levels at high aspirin doses.
What this interaction means in plain words
Acetylsalicylic acid and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Bumetanide belongs to Cardiovascular.
Why it happens
Inhibition of renal prostaglandins reduces diuretic response; competition for renal tubular secretion may raise salicylate levels.
What to do
Monitor fluid status, weight and renal function, and increase the diuretic dose if response is reduced. Prefer low-dose aspirin where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Acetylsalicylic acid with Bumetanide?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin, particularly at analgesic doses, can reduce the diuretic and natriuretic response to loop diuretics and may impair renal function in volume-depleted patients. Bumetanide can also raise salicylate levels at high aspirin doses.
How serious is the interaction between Acetylsalicylic acid and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid status, weight and renal function, and increase the diuretic dose if response is reduced. Prefer low-dose aspirin where possible.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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