Drug interactions
Bumetanide + Captopril-hydrochlorothiazide
Severity: Major
Bumetanide and Captopril-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide produces sequential nephron blockade, causing marked diuresis, hypokalemia, hyponatremia, hypomagnesemia and volume depletion. With captopril, hypotension and acute kidney injury are more likely.
What this interaction means in plain words
Bumetanide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive natriuresis and potassium wasting at different nephron sites, with volume depletion potentiating ACE inhibitor hypotension and renal effects.
What to do
Monitor electrolytes, creatinine, weight and blood pressure closely, particularly in the first weeks. Reduce diuretic doses or replace potassium and magnesium as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Bumetanide
- Amifostine + Bumetanide Major
- Amikacin + Bumetanide Major
- Bumetanide + Carbenoxolone Major
- Bumetanide + Cisplatin Major
- Bumetanide + Digoxin Major
- Bumetanide + Ethacrynic acid Major
Frequently asked questions
Can I take Bumetanide with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as major. Bumetanide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a loop diuretic with a thiazide produces sequential nephron blockade, causing marked diuresis, hypokalemia, hyponatremia, hypomagnesemia and volume depletion. With captopril, hypotension and acute kidney injury are more likely.
How serious is the interaction between Bumetanide and Captopril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure closely, particularly in the first weeks. Reduce diuretic doses or replace potassium and magnesium as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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