Drug interactions
Acetylsalicylic acid + Digoxin
Severity: Minor
Acetylsalicylic acid and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low-dose aspirin has no meaningful interaction with digoxin. High-dose salicylates may reduce renal function and slightly raise digoxin levels, but this is rarely significant in practice.
What this interaction means in plain words
Acetylsalicylic acid and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Digoxin belongs to Cardiovascular.
Why it happens
High-dose salicylates may reduce renal prostaglandin-dependent clearance of digoxin; no established effect at low doses.
What to do
No action is needed with low-dose aspirin; consider checking digoxin levels and renal function if sustained high-dose aspirin is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetylsalicylic acid and Digoxin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Acetylsalicylic acid with Digoxin?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Low-dose aspirin has no meaningful interaction with digoxin. High-dose salicylates may reduce renal function and slightly raise digoxin levels, but this is rarely significant in practice.
How serious is the interaction between Acetylsalicylic acid and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed with low-dose aspirin; consider checking digoxin levels and renal function if sustained high-dose aspirin is started.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
