Drug interactions
Digoxin + Squill
Severity: Contraindicated
Digoxin and Squill: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides (scilliroside-type bufadienolides) with digoxin-like activity. Combined use produces additive effects and a high risk of digitalis toxicity, including arrhythmias, nausea and visual disturbances.
What this interaction means in plain words
Digoxin and Squill are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive inhibition of Na+/K+-ATPase from the glycosides in squill and digoxin.
What to do
Avoid squill in patients taking digoxin. If exposure has occurred, check digoxin level, potassium and ECG.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
- Amphotericin b + Digoxin Major
Frequently asked questions
Can I take Digoxin with Squill?
MediHelp rates the interaction as contraindicated. Digoxin and Squill are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Squill contains cardiac glycosides (scilliroside-type bufadienolides) with digoxin-like activity. Combined use produces additive effects and a high risk of digitalis toxicity, including arrhythmias, nausea and visual disturbances.
How serious is the interaction between Digoxin and Squill?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid squill in patients taking digoxin. If exposure has occurred, check digoxin level, potassium and ECG.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Adagrasib, Amiodarone. The full list is on the Digoxin page.
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