Drug interactions
Digoxin + Lily of the valley
Severity: Contraindicated
Digoxin and Lily of the valley: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley (Convallaria majalis) contains cardiac glycosides such as convallatoxin. Combined with digoxin it causes additive glycoside effects and risk of digitalis toxicity with serious arrhythmias.
What this interaction means in plain words
Digoxin and Lily of the valley are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive Na+/K+-ATPase inhibition from plant cardiac glycosides and digoxin.
What to do
Avoid lily of the valley preparations during digoxin therapy. If ingestion occurs, obtain ECG, potassium and digoxin level and manage as glycoside toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Digoxin
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
- Amphotericin b + Digoxin Major
Frequently asked questions
Can I take Digoxin with Lily of the valley?
MediHelp rates the interaction as contraindicated. Digoxin and Lily of the valley are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lily of the valley (Convallaria majalis) contains cardiac glycosides such as convallatoxin. Combined with digoxin it causes additive glycoside effects and risk of digitalis toxicity with serious arrhythmias.
How serious is the interaction between Digoxin and Lily of the valley?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lily of the valley preparations during digoxin therapy. If ingestion occurs, obtain ECG, potassium and digoxin level and manage as glycoside toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Squill, Adagrasib, Amiodarone. The full list is on the Digoxin page.
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