Drug reference
digoxin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Inotropics)
Mechanism of action
Digoxin inhibits Na-K ATPase, which in turn causes increased availability of intracellular calcium in the myocardium and conduction system. Inotropy and automaticity are subsequently increased while conduction velocity is reduced. Therapy indirectly causes parasympathetic stimulation of autonomic nervous system.
Common side effects
- Dizziness
- Vomiting
- Headache
- Nausea
- Mental disturbances
- Maculopapular rash
- Diarrhea
Contraindications
- Ventricular fibrillation
Known interactions (14)
- amiodarone + digoxin Major
- clarithromycin + digoxin Major
- digoxin + Furosemide Major
- digoxin + Gentamicin Major
- digoxin + Torsemide Major
- digoxin + verapamil Major
- Amoxicillin/Clavulanate + digoxin Moderate
- Ciprofloxacin + digoxin Moderate
- digoxin + doxycycline Moderate
- digoxin + Metoprolol Moderate
- digoxin + Nebivolol Moderate
- digoxin + pantoprazole Moderate
- digoxin + sucralfate Moderate
- digoxin + Theophylline Moderate
Related conditions
Frequently asked questions
What drug class is digoxin?
digoxin belongs to: Cardiovascular.
How does digoxin work?
Digoxin inhibits Na-K ATPase, which in turn causes increased availability of intracellular calcium in the myocardium and conduction system. Inotropy and automaticity are subsequently increased while conduction velocity is reduced. Therapy indirectly causes parasympathetic stimulation of autonomic nervous system.
What are the common side effects of digoxin?
Dizziness, Vomiting, Headache, Nausea, Mental disturbances, Maculopapular rash, Diarrhea
Which drugs interact with digoxin?
amiodarone, clarithromycin, Furosemide, Gentamicin, Torsemide, verapamil, Amoxicillin/Clavulanate, Ciprofloxacin, doxycycline, Metoprolol, Nebivolol, pantoprazole, sucralfate, Theophylline
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