Drug interactions
Aspirin + Ethinyl estradiol-drospirenone
Severity: Minor
Aspirin and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise serum potassium, and NSAIDs may contribute to hyperkalemia. At low antiplatelet doses of aspirin, the effect on potassium is negligible, while higher anti-inflammatory doses are more relevant.
What this interaction means in plain words
Aspirin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive potassium retention: drospirenone blocks aldosterone, and high-dose aspirin may reduce renal prostaglandin-mediated potassium excretion.
What to do
No routine monitoring is needed with low-dose aspirin. Check serum potassium in the first cycle if high-dose aspirin is taken long term or renal function is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Aspirin with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Aspirin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone can raise serum potassium, and NSAIDs may contribute to hyperkalemia. At low antiplatelet doses of aspirin, the effect on potassium is negligible, while higher anti-inflammatory doses are more relevant.
How serious is the interaction between Aspirin and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine monitoring is needed with low-dose aspirin. Check serum potassium in the first cycle if high-dose aspirin is taken long term or renal function is impaired.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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