Drug interactions
Acetylsalicylic acid + Glipizide
Severity: Moderate
Acetylsalicylic acid and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose salicylates can enhance the glucose lowering of sulfonylureas and cause hypoglycemia. Low-dose aspirin is unlikely to have a meaningful effect.
What this interaction means in plain words
Acetylsalicylic acid and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Glipizide belongs to Endocrine.
Why it happens
Salicylates have intrinsic glucose-lowering effects and may displace sulfonylureas from protein binding.
What to do
Monitor blood glucose when starting or stopping regular analgesic-dose aspirin and reduce the glipizide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Glipizide
Frequently asked questions
Can I take Acetylsalicylic acid with Glipizide?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose salicylates can enhance the glucose lowering of sulfonylureas and cause hypoglycemia. Low-dose aspirin is unlikely to have a meaningful effect.
How serious is the interaction between Acetylsalicylic acid and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping regular analgesic-dose aspirin and reduce the glipizide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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