Drug interactions
Glipizide + Insulin degludec-liraglutide
Severity: Major
Glipizide and Insulin degludec-liraglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding insulin and a GLP-1 agonist to glipizide raises the risk of hypoglycemia, which can be serious. Sulfonylurea doses often need reduction.
What this interaction means in plain words
Glipizide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glipizide belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Additive stimulation of insulin secretion and insulin effect, producing synergistic glucose lowering.
What to do
Consider lowering the glipizide dose when this combination is started. Monitor glucose frequently and teach the patient to recognize hypoglycemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Glipizide
- Disopyramide + Glipizide Major
- Fluconazole + Glipizide Major
- Glipizide + Insulin glargine-lixisenatide Major
- Glipizide + Sulfamethoxazole Major
- Aceclofenac + Glipizide Moderate
- Acemetacin + Glipizide Moderate
Frequently asked questions
Can I take Glipizide with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Glipizide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding insulin and a GLP-1 agonist to glipizide raises the risk of hypoglycemia, which can be serious. Sulfonylurea doses often need reduction.
How serious is the interaction between Glipizide and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when this combination is started. Monitor glucose frequently and teach the patient to recognize hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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